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Alcohol linked to brain damage for heavy drinkers, study finds

Drinking eight or more alcoholic beverages each week could have a damaging effect on the brain, according to a new study published in Neurology, the medical journal of the American Academy of Neurology (AAN).

WVU Medicine Live Healthy WV - Movement Disorders: Is it Parkinson's or Essential Tremor?

Parkinson’s disease and essential tremor are movement disorders that are mostly diagnosed in older adults and share one common symptom: tremors. That’s why the two diseases are often confused for one another. 

AIUM: The future is bright for therapeutic ultrasound

Ali Rezai, MD, discussed current and potential applications of therapeutic soundwaves in medicine. He also shared examples of studies showing the efficacy of these treatments.

Mother with rare ALS touts 'miracle drug' that has stopped her disease

QALSODY is designed specifically to treat the SOD1 form of ALS by lowering the toxic effects of the mutations in the SOD1 gene.

Picking your brain

In the Department of Neuroscience at the West Virginia University School of Medicine, part of the Rockefeller Neuroscience Institute, researchers are learning how the central nervous system is influenced by internal factors, such as genetics, and outside influences in our living environment.

‘Gas station heroin’ arises as a new threat

Known as “gas station heroin” and marketed as a mood-enhancing herbal supplement, tianeptine is quietly finding its way into the hands of consumers, many of whom are unaware of its addictive properties and overdose dangers, substance abuse experts say.

Spinal cord stimulation restores movement for people with 'muscle wasting' disorder

People with spinal muscle atrophy (SMA), an inherited neuromuscular disease, usually experience muscle weakness that impacts movement. New research suggests that electrical spinal cord stimulation could improve muscle function for these patients, even restoring the capability to walk.

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Could Ultrasound Help Treat Addiction?

The future of addiction treatment could be in treating the brain itself. A new trial at the RNI is exploring whether using ultrasound waves on parts of the brain associated with addiction could disrupt connections that contribute to cravings.

Neurosurgeon pioneers Alzheimer's, addiction treatments using ultrasound

The WVU Rockefeller Neuroscience Institute uses the latest technologies, an ecosystem of partners, and an integrated approach to make meaningful progress in the advancement of brain health. Its published works detailing breakthroughs in the treatment of Alzheimer’s disease and addiction caught the attention of producers of the iconic CBS News program, 60 Minutes.

RNI breakthrough work in focused ultrasound featured in American Scientist

RNI’s continued success in pioneering treatments for Parkinson’s and essential tremor using focused ultrasound (FUS) was recently covered in American Scientist. The article, entitled, “Brain Surgery Without a Knife,” features Dr. Ali Rezai who also details the possibilities of using FUS for Alzheimer’s and even addiction.

Headshots of Drs. Rezai and Murray alongside a screenshot of the news story.

MeiraGTx’s Parkinson’s gene therapy shows promise in Phase I/II study

APhase I/II trial (NCT05603312) with MeiraGTx‘s AAV-GAD Parkinson’s disease gene therapy has met its primary endpoint.

 

Can Zapping the Brain Help Treat Addiction?

A radical experiment uses focused ultrasound waves to reset cells inside the brain’s reward center to combat cravings.

Dr. Ali Rezai, live from the Milken Global Conference

In this clip from Bloomberg TV, Dr. Ali Rezai discusses Alzheimer’s and addiction research at the WVU Rockefeller Neuroscience Institute and the importance of building strong partnerships.

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An Ultrasound Experiment Tackles a Giant Problem in Brain Medicine

The investigators, at the Rockefeller Neuroscience Institute at West Virginia University, reported their results last week in The New England Journal of Medicine. When the barrier was opened, 32 percent more plaque was dissolved, said Dr. Ali Rezai, a neurosurgeon at the institute, who led the study. 

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Opening Blood-Brain Barrier to Deliver Alzheimer's Drug Shows Promise

Aducanumab (Aduhelm) infusions combined with focused ultrasound led to lower cerebral amyloid-beta levels in Alzheimer’s disease, a proof-of-concept trial showed. The investigational treatment involved creating an opening in the blood-brain barrier with MRI-guided focused ultrasound to boost drug delivery.

This Pill Tracks Your Vitals From the Inside

An ingestible “digital pill” that measures heart rate and breathing from inside the stomach could detect the warning signs of sleep apnea, cardiac distress, and even opioid overdoses.

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A neurology professor weighs in on the health questions surrounding Mitch McConnell

For a second time in a little over a month, Senate Minority Leader Mitch McConnell appeared to freeze up while taking questions a press conference, raising questions about his health.

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Neuralink competitor Precision Neuroscience conducts its first clinical study to map human brain signals

It happened so fast that Craig Mermel missed it. He was standing in a busy operating room in West Virginia, waiting for a surgeon to place Precision Neuroscience’s neural implant system onto a conscious patient’s brain for the first time. 

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WVU addresses addiction crisis with novel ultrasound treatment

On the heels of the country’s deadliest year for drug overdoses, the West Virginia University Rockefeller Neuroscience Institute launched a first-in-the-world clinical trial to investigate the use of focused ultrasound technology to treat those with opioid use disorder. 

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Experimental brain surgery may help some people overcome drug addiction

When her son bounced up the steep stone steps and through the door of the house he shared with his mother and father, Gina Buckhalter was wary. It was no secret that Gerod was a heavy drug user, addicted to opioids for more than half his 33 years.

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Addiction treatment had failed. Could brain surgery save him?

After nearly two decades of hardcore drug addiction — after overdoses and rehabs and relapses, homelessness and dead friends and ruined lives — Gerod Buckhalter had one choice left, and he knew it.

AASPT Casual Stats with Matt Tenan, PhD

Dr. Matthew Tenan joined the American Academy of Sports Physical Therapy’s “Casual Stats” podcast for an insightful conversation on statistics and scientific rigor in physical medicine.

ECHO Model program expands opportunities for West Virginia opioid treatment

For many people across the region, finding access to healthcare can be a challenge. That’s why some West Virginia providers are working together using a new method called the ECHO Model in the hopes of improving healthcare.

Movement Disorders Affect West Virginians at Higher Rates; WVU Medicine Encourages Awareness and Treatment

Movement disorders impact West Virginians at a higher rate than the national average, and WVU Medicine hopes those affected will recognize the signs and symptoms and seek care.

 

The Good News About Overdose Deaths in the U.S.

New data from the CDC’s National Vital Statistics System released in February 2025 revealed nearly a 24% decline in drug overdose deaths in the United States for the 12 months ending in September 2024 compared to the previous year.

WVU RNI investigates new mesh device to treat brain aneurysms

WVU Rockefeller Neuroscience Institute continues its mission to advance treatment of brain aneurysms with its participation in the clinical trial of a new device called SEAL. SEAL stands for Saccular Endovascular Aneurysm Lattice, and manufacturer Galaxy Therapeutics calls their creation the SEAL Embolization System.

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Neuromodulation in Addiction Treatment

Emerging neuromodulation approaches are being explored as potential treatment options for substance use disorders (SUDs). Dr. James H. Berry tells Psychology Today how the RNI is leading the way.

Brain injuries often go unrecognized among domestic violence victims

Domestic violence survivors often face unseen injuries, including brain trauma. Dr. Javier Cardenas spoke with NBC News, highlighting the RNI’s innovative treatments that help survivors heal and regain their strength.

Dr. James Mahoney was quoted by the Pittsburgh Post-Gazette about the effects of moderate alcohol use.

Report finds some benefits to moderate drinking

A new report from The National Academies of Sciences, Engineering, and Medicine suggests that there are benefits to moderate drinking.

However, Dr. James J. Mahoney told the Pittsburgh Post-Gazette there are potential unintended consequences if the risks are overshadowed by the benefits.

DBS stimulation for spinal cord injuries

A new brain therapy offers hope for paralyzed patients gifting them with regained movement. RNI’s Dr. Ann Murray offered her insights, calling the study’s results, “suprising and exciting.” She added, “As we continue to better understand the brain networks, it will continue to enable us to modulate areas that aren’t working correctly.”

Blood Test Can Benefit NFL Concussion Return-to-Play Decisions

In February 2018, the U.S. Food and Drug Administration approved the marketing of the nation’s first-ever blood test to evaluate traumatic brain injury. An updated, handheld version of the test was released this past April by Abbott, which can even be used at a patient’s bedside.

Ultrasound technology is used in many ways. Addiction is the next frontier.

The April clinical trial session at West Virginia University’s Rockefeller Neuroscience Institute opens a window into a growing school of research that repurposes a tried-and-true scientific tool, ultrasound, in a more focused fashion.

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Sound waves get Alzheimer’s drug past brain barrier, small study shows

In the first study of its kind in humans, researchers have discovered that it is safe to use sound waves fired into specific areas of the brain to open a protective barrier and clear the way for Alzheimer’s medications.

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Alzheimer’s drugs might get into the brain faster with new ultrasound tool, study shows

Scientists have found a way to help Alzheimer’s drugs seep inside the brain faster — by temporarily breaching its protective shield. The novel experiment was a first attempt in just three patients.

Can brain ultrasound treat addiction? A cocaine study may hold answers.

Substance use disorder afflicts many Americans — in 2021, 46.3 million people in the United States age 12 or older were addicted to alcohol or drugs such as opioids and stimulants. Now scientists are studying a promising and surprisingly familiar therapy that can help reset the brain and stem the cravings of addiction.

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People Let a Startup Put a Brain Implant in Their Skull—for 15 Minutes

Elon Musk’s Neuralink isn’t the only company making progress on connecting people’s brains to computers. In April and May, surgeons at West Virginia University placed thin strips of a cellophane-like material on the brains of three patients. 

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A Hole in the Head: Can a brain implant treat drug addiction?

On a bright summer day in July 2021, James Fisher rested nervously, with a newly shaved head, in a hospital bed surrounded by blinding white lights and surgeons shuffling about in blue scrubs.

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Deep brain stimulation may ease opioid addiction when other treatments fail

Doctors at West Virginia University’s Rockefeller Neuroscience Institute are testing the experimental procedure on patients for whom other treatments didn’t work.

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Mars? The next frontier is much closer

What is it about a frontier? Whether it is a continent, the Moon or, today, the planet Mars, a frontier is a powerful motivator that speaks to a drive inside all of us to go further and higher.

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Brain surgery may combat opioid addiction

Deep brain stimulation, or DBS, via pacemaker technology may help those battling the addiction, which kills 128 Americans every day.

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Can ultrasound be used to fight Alzheimer’s?

t age 61, Judi Polak is five years into a bleak diagnosis: Alzheimer’s disease. But last year she made medical history in a clinical trial, when a team of scientists, engineers and practitioners deployed a novel device to take aim at a big barrier in the fight against her illness. 

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